Manchester United vs Lyon Prediction: Can Ruben Amorim's side salvage the season with European success?

Manchester United vs Lyon UEFA Europa League Prediction Match Details

The quarter-final of the Europa League second leg kicks off its showdown on Thursday night, with Manchester United set to welcome Lyon to Old Trafford. The first leg ended in a 2-2 draw, but can Rúben Amorim's side salvage the season with European success?

Manchester United Preview & Form

Manchester United's only chance of winning silverware and playing Champions League football next season in Ruben Amorim's debut season would be if the Red Devils continue their unbeaten run in European competitions. United, despite their miserable season, have been one of the strongest teams in the Europa League, with the Red Devils remaining the only unbeaten side in continental action. The first leg of their quarterfinal game ended in a disappointing 2-2 draw against Lyon at Groupama Stadium in France following a pair of mistakes from Andre Onana, who was subsequently left out of the squad against Newcastle United in the Premier League. The Red Devils are now winless in the last four games across all competitions following another disappointing 4-1 defeat against Newcastle United in the domestic league.

Lyon Preview & Form

Lyon will arrive in England on the back of a brilliant run of form, having won seven of their last ten games in all competitions. Last weekend, Lyon claimed their seventh victory in nine matches by beating Auxerre 3-1 away in their domestic league, and this will boost their confidence going to Old Trafford. Paulo Fonseca’s side are sitting fourth with 51 points and are in a good position to qualify for Champions League football next season. Lyon has been solid in this season's Europa League, remaining undefeated in the last seven games with two or more goals scored in five of the games, including the first leg with United.

Manchester United vs Lyon Predicted Lineups

Update: Joshua Zirkzee, has been ruled out for the rest of the season.

Manchester United: Onana; Yoro, Maguire, Mazraoui; Dalot, Casemiro, Ugarte, Dorgu; Fernandes, Mount; Zirkzee.
Lyon: Perri; Maitland-Niles, Mata, Niakhate, Vinicius; Matic, Veretout; Mikautadze, Cherki, Tolisso; Lacazette. 

Manchester United vs Lyon H2H Record (Last Five Games)

• April 10, 2025 – UEFA Europa League Quarter-Final, First Leg
  Lyon 2–2 Manchester United

• March 5, 2008 – UEFA Champions League Round of 16, Second Leg
  Manchester United 1–0 Lyon
  United advanced to the quarter-finals with a narrow win.

• February 20, 2008 – UEFA Champions League Round of 16, First Leg
  Lyon 1–1 Manchester United
  A balanced match with both teams sharing the spoils.

• November 24, 2004 – UEFA Champions League Group Stage
  Manchester United 2–1 Lyon
  United clinched a home victory, solidifying their group stage performance.

• September 16, 2004 – UEFA Champions League Group Stage
  Lyon 2–2 Manchester United
  Lyon took an early 2-0 lead, but United fought back to secure a draw.

Manchester United vs Lyon Prediction Betting Tips

Both teams have demonstrated consistency in European competitions, but Manchester United seems to have a slight advantage over Lyon in the second leg of their Europa League quarter-final at Old Trafford. So we think Ruben Amorim's side will fancy home advantage in this game.

Bet:

Manchester United to Win or Draw
Both Teams to Score and Over 2.5 Goals
Over 10.5 Corners